Small marker chromosomes in man: origin from pericentric heterochromatin of chromosomes 1, 9, and 16.
- 1 March 1990
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 27 (3), 155-159
- https://doi.org/10.1136/jmg.27.3.155
Abstract
Three patients with different marker chromosomes were screened by in situ hybridisation using biotinylated probes to chromosome specific pericentric repeats to detemrine the chromosomal origin of the marker. Each marker had a different origin, with one from each of chromosomes 1, 9, and 16. This is the first time that autosomal marker chromosomes consisting of a small ring have been shown to be derived from the pericentric heterochromatin of metacentric and submetacentric chromosomes. Evidence suggests that such markers are not associated with any significant risk of phenotypic abnormalities, but additional cases need to be studied.This publication has 13 references indexed in Scilit:
- Chromosome-specific alpha satellite DNA: Isolation and mapping of a polymorphic alphoid repeat from human chromosome 10Genomics, 1988
- Determining the origin of human X isochromosomes by use of DNA sequence polymorphisms and detection of an apparent i(Xq) with Xp sequencesHuman Genetics, 1987
- Genomic Organization of Human Centromeric Alpha Satellite DNA: Characterization of a Chromosome 17 Alpha Satellite SequenceDNA, 1987
- Marker chromosomes in A series of 10000 prenatal diagnoses. Cytogenetic and follow‐up studiesPrenatal Diagnosis, 1987
- Hierarchical order in chromosome-specific human alpha satellite DNATrends in Genetics, 1987
- Two subsets of human alphoid repetitive DNA show distinct preferential localization in the pericentric regions of chromosomes 13, 18, and 21Cytogenetic and Genome Research, 1986
- Sensitive system for visualising biotinylated DNA probes hybridised in situ: rapid sex determination of intact cells.Journal of Clinical Pathology, 1985
- MOLECULAR ARRANGEMENT AND EVOLUTION OF HETEROCHROMATIC DNAAnnual Review of Genetics, 1980
- Cytogenetic and clinical studies in five cases of inv dup(15)Human Genetics, 1979
- Preferential derivation of abnormal human G-group-like chromosomes from chromosome 15Human Genetics, 1977