Detection of Viruslike Particles in Germ-Free Mice
- 1 November 1965
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 90 (5), 1448-+
- https://doi.org/10.1128/jb.90.5.1448-1454.1965
Abstract
Viruslike particles similar in structure to the mouse leukemia agent were detected by electron microscopy in thymus tissues of germ-free AK mice which had developed spontaneous leukemia. In addition, unique viruslike particles (type B) were detected in tissues from spontaneous mammary adenocarcinoma of germ-free C3H mice. Leukemia viruslike particles were also observed in the thymuses of the control AK mice and of the C3H control mice as well as of those with mammary tumors. Germ-free mice are not virus-free. The routes of transmission of leukemia as well as of mammary tumor viruses may be "vertical, " through the embryo or placenta.This publication has 27 references indexed in Scilit:
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