THE RELATIVE THYROIDAL POTENCY OF 1- AND d,1-THYROXINE1
- 1 March 1945
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 36 (3), 200-206
- https://doi.org/10.1210/endo-36-3-200
Abstract
The thyroidal potency of 1-thyroxine ([d]D = -4.2, M.P. : 236-238[degree]C.) obtained by acid hydrolysis and d,l-thyroxine obtained by Ba-hydrolysis of thyroidally active iodinated casein was compared by biological assays. As detd. by its ability to reduce the thyroid wt. of thiouracil-treated chicks and rats and its stimulation of metamorphosis of Rana Pipiens larvae 1-thyroxine exerted twice the effect of the racemic compound in every instance. This confirmed the results of previous comparisons made on guinea pigs. Since 1-thyroxine uniformly produced twice the effect of the d,l-mixture in 4 species of test animals it is concluded that all of the activity of racemic thyroxine must reside in the l-component, and that the d-compound has little or no activity.This publication has 7 references indexed in Scilit:
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