Assignment of the Human Interferon-α Receptor Gene to Chromosome 21q22.1 by In Situ Hybridization
- 1 January 1990
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 10 (5), 515-517
- https://doi.org/10.1089/jir.1990.10.515
Abstract
The human interferon-.alpha. receptor gene (IFN AR) has been assigned to the long arm of human chromosome 21 (report of the committee on the genetic constitution of chromosomes 20 and 21; Ref 1). The present report confirms the assignment and refines the mapping to the 21q22.1 band, using a cDNA probe for the human IFN AR gene and in situ hybridization to metaphase chromosomes.This publication has 12 references indexed in Scilit:
- Genetic transfer of a functional human interferon α receptor into mouse cells: Cloning and expression of its c-DNACell, 1990
- Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.Molecular and Cellular Biology, 1989
- Report of the committee on the genetic constitution of chromosomes 20 and 21Cytogenetic and Genome Research, 1989
- 125I-labelled Human Interferons Alpha, Beta and Gamma: Comparative Receptor-binding DataJournal of General Virology, 1985
- DNA probe localization at 18p113 band by in situ hybridization and identification of a small supernumerary chromosomeHuman Genetics, 1985
- Receptors for human alpha and beta interferon but not for gamma interferon are specified by human chromosome 21.Proceedings of the National Academy of Sciences, 1984
- Direct evidence that the gene product of the human chromosome 21 locus, IFRC, is the interferon-α receptorBiochemical and Biophysical Research Communications, 1982
- Enhanced expression of cellular receptors for human interferon α on peripheral lymphocytes from patients with down's syndromeFEBS Letters, 1982
- Genes coding for sensitivity to interferon (IfRec) and soluble superoxide dismutase (SOD-1) are linked in mouse and man and map to mouse chromosome 16.Proceedings of the National Academy of Sciences, 1980
- Antibodies to a cell-surface component coded by human chromosome 21 inhibit action of interferonNature, 1976