Perception, attention, and working memory are disproportionately impaired in dementia with Lewy bodies compared with Alzheimer's disease
- 1 February 2001
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 70 (2), 157-164
- https://doi.org/10.1136/jnnp.70.2.157
Abstract
OBJECTIVE—To test the hypotheses that visuoperceptual and attentional ability are disproportionately impaired in patients having dementia with Lewy Bodies (DLB) compared with Alzheimer's disease (AD). METHODS—A comprehensive battery of neuropsychological tasks designed to assess working, episodic, and semantic memory, and visuoperceptual and attentional functions was given to groups of patients with DLB (n=10) and AD (n=9), matched for age, education, and mini mental state examination (MMSE), and to normal controls (n=17). RESULTS—Both patient groups performed equally poorly on tests of episodic and semantic memory with the exception of immediate and delayed story recall, which was worse in the AD group. Digit span was by contrast spared in AD. The most striking differences were on tests of visuoperceptual/spatial ability and attention. Whereas patients with AD performed normally on several subtests of the visual object and space perception battery, the DLB group showed substantial impairments. In keeping with previous studies, the AD group showed deficits in selective attention and set shifting, but patients with DLB were more impaired on virtually every test of attention with deficits in sustained, selective, and divided attention. CONCLUSIONS—Patients with DLB have substantially greater impairment of attention, working memory, and visuoperceptual ability than patients with AD matched for overall dementia severity. Semantic memory seems to be equally affected in DLB and AD, unlike episodic memory, which is worse in AD. These findings may have relevance for our understanding of the genesis of visual hallucinations, and the differential diagnosis of AD and DLB.Keywords
This publication has 35 references indexed in Scilit:
- Impaired Acquisition and Rapid Forgetting of Patterned Visual Stimuli in Alzheimer's DiseaseJournal of Clinical and Experimental Neuropsychology, 1998
- Motor and cognitive function in Lewy body dementia: comparison with Alzheimer's and Parkinson's diseases.Journal of Neurology, Neurosurgery & Psychiatry, 1997
- Neuropathological Brain MappingDementia and Geriatric Cognitive Disorders, 1997
- Diffuse Lewy body disease: clinical features in nine cases without coexistent Alzheimer's disease.Journal of Neurology, Neurosurgery & Psychiatry, 1996
- Dual‐Task Paradigm: A Means To Examine the Central ExecutiveAnnals of the New York Academy of Sciences, 1995
- SEMANTIC DEMENTIABrain, 1992
- Operational criteria for senile dementia of Lewy body type (SDLT)Psychological Medicine, 1992
- Separate visual pathways for perception and actionTrends in Neurosciences, 1992
- Dementia and Working MemoryThe Quarterly Journal of Experimental Psychology Section A, 1986
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984