Qualitative and Quantitative Changes in Alkaline Phosphatase Activity of Regenerating Rat Liver

Abstract

The relationship between increased alkaline phosphatase activity of regenerating liver tissue and sensitivity to cyanide poisoning and Mg acceleration was studied in young adult male Wistar rats subjected to partial hepatectomy. Consideration was given to changes in total enzyme content, concn./g. of protein, plasma levels and effects on activity of amt. of liver excised, rate of hepatic protein synthesis, cell division and nutritive state of the animal. The postoperative increase in content and concn. of hepatic alkaline phosphatase results from a cyanide-sensitive, Mg insensitive enzyme component. Increased phosphatase activity of liver may result from impaired elimination of plasma phosphatase via the bile.