Influence of Parathyroid Extract on Citric Acid of the Serum

Abstract

The subcut. injn. of parathyroid extract into normal and thyroparathyroidectomized rats results in definite increases in the serum citric acid level. Dose-response data indicate that the rise in serum citrate varies with the dose of the extract, the route of the injn. and the period of observation. The level of serum citrate of thyroparathyroidectomized rats was found to be significantly lower than that of normal animals. Increased sensitivity and greater uniformity of response to the injd. dose were observed in the operated animals as compared to normal animals.