A microcomputer program for analysis of a binomial proportion and the common odds ratio in a series of 2 x 2 tables is presented. This program utilizes both exact and asymptotic methods to provide point estimates, P values, and confidence intervals. Modifications of the exact method based on the concept of a mid-P value are also included. The program allows the user to compare the exact coverage properties of various methods of computing confidence intervals. Use of an improved algorithm provides considerable gains in computational efficiency.