THE EFFECT OF NICOTINE ON UTERINE RESPONSES TO HYPOGASTRIC NERVE STIMULATION

Abstract

In the uterus of the monkey and of the bitch nicotine in suitable doses abolished the motor effect of hypogastric nerve stimulation. The inhibitory phase in the monkey was not affected by nicotine. The evidence suggests that the hypogastric nerves in the monkey contain pre-ganglionic motor fibers and postganglionic inhibitory fibers to the uterine musculature, and in the bitch preganglionic motor fibers. The motor fibers to the uterus contained in the hypogastric nerves of the monkey and bitch are probably cholinergic in nature.