Spontaneously Acquired Factor VIII Inhibitor in a 7-Year-Old Girl

Abstract

The youngest case with spontaneously acquired inhibitor to factor VIII is reported. A 7-yr-old girl without any previous disorders presented with a hemarthrosis in the left knee and developed a rapidly expanding hematoma on the right arm, shoulder and chest after an initial infusion of factor VIII concentrate (1000 U). Circulating anti-factor VIII antibody was detected. Her coagulopathy was successfully managed with an additional massive infusion of factor VIII concentrate (7500 U) and combination therapy of prednisolone and cyclophosphamide.