This is the first study shows that the implementation of a standardized management of septic shock, as outlined by Rivers et al. {1}, was associated with statistically lower 28-day mortality (48.3% versus 30.0%). These data confirm that the use of standardized order sets for the management of septic shock could, and should be routinely employed. It was a before-after study design with 120 consecutive patients with septic shock admitted in an emergency department (ED). Patients in the after group received statistically more intravenous fluids while in the ED (2825 versus 3789ml ), received more transfusion of RBC units (7% versus 20%), and were more likely to be treated earlier with an appropriate initial antimicrobial regimen. This study strongly suggest that ED physicians should follow the Surviving Sepsis Campaign guidelines {2}, which recommends a package of evidence-based interventions to improve outcomes for the critically septic patient.