The Efficacy and Safety of Divalproex Sodium in the Treatment of Acute Mania in Adolescents and Young Adults
- 1 April 1995
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Journal of Clinical Psychopharmacology
- Vol. 15 (2), 110-116
- https://doi.org/10.1097/00004714-199504000-00006
Abstract
This open clinical trial investigated the potential short-term efficacy and safety of divalproex sodium in the treatment of adolescents and young adults with bipolar affective disorder in an acute manic phase. Fifteen subjects were treated for 7 weeks with divalproex sodium (mean drug level in blood +/- the standard deviation at trial completion, 642.85 +/- 183.08 micro mol/liter) and were assessed weekly with the Modified Mania Rating Scale (MMRS), the Brief Psychiatric Rating Scale (BPRS), the Global Assessment Scale (GAS), and the Clinical Global Impressions Scale (CGI). Of the 15 subjects who entered the study, 8 showed marked improvement on the MMRS (pre-post decrease of greater or equal to 75%), 4 showed moderate improvement (pre-post decrease of 50 to 74%), 1 showed some improvement (pre-post decrease of 25 to 49%), 1 showed no improvement and was withdrawn before the seventh study week because of lack of response, and 1 withdrew because of side effects. The mean MMRS score was significantly changed by 7 weeks of treatment in the 13 subjects who completed the 7-week trial (69.54 +/- 24.21 to 18.08 +/- 8.70; t = 7.72; pKeywords
This publication has 29 references indexed in Scilit:
- Adolescent versus adult onset of maniaAmerican Journal of Psychiatry, 1988
- Affective Disorders in Referred Children and Younger Siblings of Manic-DepressivesArchives of General Psychiatry, 1985
- Age at onset in bipolar-related major affective illness: Clinical and genetic implicationsJournal of Psychiatric Research, 1983
- Bipolar Illness in Adolescents With Major DepressionArchives of General Psychiatry, 1982
- Affective Disorders in AdolescencePsychiatric Clinics of North America, 1979
- Age at Onset of Bipolar Affective IllnessArchives of General Psychiatry, 1978
- From Shaman to Psychotherapist: A History of the Treatment of Mental IllnessAmerican Journal of Psychiatry, 1977
- Follow-up of 53 Bipolar Manic-Depressive PatientsThe British Journal of Psychiatry, 1974
- A Six Year Follow-Up Study of Sixty-Five Adolescent Patients: Predictive Value of Presenting Clinical PictureThe British Journal of Psychiatry, 1969
- THE COURSE OF DEPRESSIVE PSYCHOSESActa Psychiatrica Scandinavica, 1968