Serum lipid peroxide level and blood superoxide dismutase activity in workers with occupational exposure to lead
- 1 August 1985
- journal article
- research article
- Published by Springer Nature in Internationales Archiv für Arbeitsmedizin
- Vol. 56 (2), 119-127
- https://doi.org/10.1007/bf00379383
Abstract
We studied whether lead exposure increased the serum lipid peroxide (LPO) level and inhibited blood superoxide dismutase (SOD) activity in workers with occupational exposure to lead and rats injected with lead. We examined the following subjects: (1) manual workers (712 males) from 18 to 59-years-old in steel production with occupational exposure to lead, (2) office workers (155 males) without exposure to lead, (3) rats subcutaneously injected with lead in concentrations of 10 or 20 mg/kg as lead acetate. The nutritional intakes of manual workers and office workers were approximately equal. Serum LPO and high-density lipoprotein cholesterol (HDL-CL) levels in manual workers (LPO: 4.4 ± 1.9 nmol/ml, HDL-CL: 55.6 ± 14.2 mg/dl) were significantly higher than those in office workers (LPO: 4.0 ± 1.4 nmol/ml, HDL-CL: 53.0 ± 13.9 mg/dl). Serum LPO level in the manual workers increased with an increase of the lead concentration in the blood, while blood SOD activity decreased. Similar phenomena were observed in rats subcutaneously injected with lead acetate. Furthermore, the addition of lead at higher than 20-μM concentrations to non-treated rat liver microsomes increased NADPH-dependent lipid peroxidation, and these lead concentrations inhibited bovine erythrocyte SOD activity in vitro assay system. In conclusion, the present results seem to indicate that the increase of serum LPO level in workers with occupational exposure to lead is due not only to the stimulation of lipid peroxidation, but also to the inhibition of SOD activity by exposure to lead in the manufacturing processes.This publication has 19 references indexed in Scilit:
- Cellular toxicity and lipid peroxidation in response to mercuryToxicology and Applied Pharmacology, 1982
- Free Radicals, Age Pigments, and Lipid MetabolismPublished by Elsevier ,1982
- The effect of lead on hemoglobin-catalyzed lipid peroxidationBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1981
- Lipid Peroxidation in Mitochondrial MembranePublished by Elsevier ,1980
- A simplified assay method of superoxide dismutase activity for clinical useClinica Chimica Acta; International Journal of Clinical Chemistry, 1979
- Some Biochemical and Clinical Aspects of Lead IntoxicationAdvances in Clinical Chemistry, 1978
- Heme Metabolites in Blood and Urine in Relation to Lead Toxicity and Their DeterminationAdvances in Clinical Chemistry, 1978
- A simple fluorometric assay for lipoperoxide in blood plasmaBiochemical Medicine, 1976
- Free Radical Mechanisms of Lipid Damage and Consequences for Cellular MembranesPublished by Elsevier ,1976
- Superoxide DismutasesAnnual Review of Biochemistry, 1975