Tardive Dyskinesia Associated with High-Dose Intravenous Metoclopramide

Abstract

To the Editor: A 45-year-old white man with recurrent testicular cancer underwent six courses of chemotherapy with cisplatin and etoposide during an eight-month period. During each five-day course, metoclopramide (in high intravenous doses of 2 mg per kilogram of body weight) was used as an antiemetic. The metoclopramide was usually first given 30 minutes before chemotherapy and then as needed. The patient received the following total intravenous doses: 1800 mg in course 1, 430 mg in course 2, 685 mg in course 3, 685 mg in course 4, 1080 mg in course 5, and 560 mg in course 6. He . . .