The mode of action of a new antitumor antibiotic, sporamycin.
- 1 January 1979
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 32 (4), 386-391
- https://doi.org/10.7164/antibiotics.32.386
Abstract
Sporamycin, an antitumor antibiotic, primarily inhibited DNA synthesis, while RNA and protein synthesis were not significantly affected in [human cervical carcinoma] HeLa S3 cells. The antibiotic also caused strand scission of cellular DNA. The effects were not observed when the cells were incubated at 0.degree. C before washing and subsequently incubated at 37.degree. C. The Tm [melting point] of calf thymus DNA decreased when incubated with sporamycin in vitro. Sporamycin did not affect DNA synthesis in vitro catalyzed by partially purified DNA polymerases .alpha., .beta. and .gamma. derived from [mouse] Ehrlich ascites cells.This publication has 6 references indexed in Scilit:
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- ANTITUMOR ACTIVITY OF A NEW ANTITUMOR ANTIBIOTIC, SPORAMYCIN1977
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