Post-Lesion Tremor Inhibition

Abstract

Introduction Previous studies involving acute and chronic preparations indicated that transections of the neuraxis rostral to a plane passing through the head of the caudate nucleus, diagonal band of Broca, and the subcallosal gyrus, were ineffectual in preventing tremor at rest produced by the drug Tremorine (1,4 dipyrrolidino-2-butyne, Kaelber and Hamel¹). Further attempts to localize ana tomical substrates through which this compound might be exerting some of its effects ultimately resulted in placing relatively circumscribed electrolytic lesions in various parts of the hypothalamus and certain ventrally situated thalamic nuclei. A number of these lesions proved to be effective against the tremor-producing properties of this drug. This report deals with a description of the lesions and areas destroyed relative to their effectiveness against Tremorine and some problems in correlation of specific structures with drug action. Methods Under pentobarbital (Nembutal) anesthesia bilateral electrolytic lesions were made in various parts of the