Hypocholesteremic Effect of -Diethylaminoethyl Diphenylpropylacetate Hydrochloride (SKF No. 525-A) in the Dog

Abstract

/3-Diethylaminoethyl diphenylpropylacetate hydrochloride (SKF No. 525-A) administered to dogs on a "normal" diet caused dramatic and sustained hypocholesteremic effects. Chronic daily administration of SKF No. 525-A to the dogs for 5 months resulted in marked fatty infiltration of the liver, which was rapidly reversible upon withdrawal of the compound.