Uptake, Storage, and Release of γ-Aminobutyric Acid in Normal and Chronically Denervated Cat Cerebral Cortex

Abstract

The uptake and release of γ-[³H]aminobutyric acid ([³H]-GABA) from chronically denervated, epileptic cerebral cortex of the cat has been compared with normal cortex. Both uptake and KCl-stimulated release of GABA appeared to be normal, although under the conditions of the experiment the resting release of GABA was elevated. Endogenous taurine and serine levels were increased, aspartate and glutamate decreased, while a variety of other amino acids, including GABA, were unchanged.