Localization of the Tamm‐Horsfall glycoprotein (unomodulin) gene to chromosome 16p12.3‐16p13.11
- 1 October 1993
- journal article
- Published by Wiley in Annals of Human Genetics
- Vol. 57 (4), 285-290
- https://doi.org/10.1111/j.1469-1809.1993.tb00902.x
Abstract
Mapping studies using a panel of 22 rodent-human somatic cell hybrids have helped to localize the Tamm-Horsfall glycoprotein (uromodulin) gene (UMOD), which has previously been reported to map to 16p13.11, to the region 16p12.3-qter. The combined results indicate that UMOD is located distal to D16S295 and proximal to D16S287 and in the region 16p12.3-16p13.11. Uromodulin is known to affect the formation of calcium-containing kidney stones, and this localization of UMOD will help in studies of families with autosomal forms of nephrolithiasisKeywords
This publication has 27 references indexed in Scilit:
- Chromosomal assignment of the uromodulin gene (UMOD) to 16p13.11Cytogenetic and Genome Research, 1993
- Molecular cloning and sequencing of cDNA encoding urinary stone protein, which is identical to osteopontinBiochemical and Biophysical Research Communications, 1992
- Report of the committee on the genetic constitution of chromosome 16Cytogenetic and Genome Research, 1991
- cDNA cloning, mRNA distribution and heterogeneity, chromosomal location, and RFLP analysis of human osteopontin (OPN)Genomics, 1990
- Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA PolymeraseScience, 1988
- Identification of Human Uromodulin as the Tamm-Horsfall Urinary GlycoproteinScience, 1987
- Uromodulin: A Unique 85-Kilodalton Immunosuppressive Glycoprotein Isolated from Urine of Pregnant WomenScience, 1985
- Regulation of expression of liver‐specific enzymesAnnals of Human Genetics, 1982
- Familial Idiopathic HypercalciuriaNew England Journal of Medicine, 1979
- Immunochemical analysis of the N-acetyl hexosaminidases in human-mouse hybrids made using a double selective systemCytogenetic and Genome Research, 1977