ENCEPHALITIS AND PNEUMONIA FOLLOWING THE INTRANASAL INOCULATION OF NEWCASTLE DISEASE VIEUS IN DIFFERENT STRAINS OF MICE1

Abstract

A chicken-adapted virulent strain of Newcastle disease virus ((NDV) (CG179 or CGMB)) when inoculated intra-nasally into mice, will produce either pneumonia during the first few days or encephalitis 5 to 29 days after inoculation. Following intranasal inoculation, mice of different genetically homogeneous strains showed varying degrees of susceptibility to the pneumotropic and neurotropic effects of this virus. Intra-cerebral inoculation revealed that all strains of mice were susceptible. Older mice were more resistant than the recently weaned mice to the neurotropic effects but not to the pneumotropic effects.