Mycinamicins, new macrolide antibiotics. I. Taxonomy, production, isolation, characterization and properties.

Abstract

Mycinamicins, novel macrolide antibiotics were obtained from the culture broth of Micromonospora griseorubida sp. nov. Isolation of 5 components, mycinamicins I, II, III, IV and V, was accompanied by silica gel adsorption or partition chromatography. Mycinamicin I and II exhibit a strong UV absorption peak at 218 nm and have a shoulder at 240 nm. Mycinamicin III, IV and V show strong UV absorption peaks at 215 nm and .apprx. 280 nm. From their physicochemical and biological properties, the mycinamicins are classified as new macrolide antibiotics.