Actions of Chlorpromazine and of Reserpine on Spinal Reflex Activity in the Cat

Abstract

In both decerebrate and anesthetised cats, chlorpromazine or reserpine inhibits transmission of excitation through monosynaptic pathways within the spinal cord more strongly than through polysynaptic pathways. This is most evi- dent when submaximal sensory stimuli are used. Blood pressure changes in the cats bore no temporal relation to the effects of drugs on induced potentials. Extensive bleeding in the absence of drugs often initially enhanced transmission within monosynaptic reflex arcs; poly-synaptic activity was depressed in these experiments before monosynaptic.