Effect of Beta-Aminopropionitrile on Joint Stiffness in Rats

Abstract

Rat knee joints were immobilized for 2 and 3-week periods, and [beta]-aminoproprionitrile [BAPN] was administered for various intervals during immobilization. Joint stiffness was measured by recording force necessary to extend the joint. [beta]-APN significantly reduced stiffness when given throughout a 3-week period of immobilization, and to a lesser degree when given during the 3rd week of immobilization only. There was no significant effect when the drug was administered during just the 1st week of immobilization. In rats whose joints were immobilized for 4 weeks, [beta]-aminopropionitrile administered for 3 days following removal of the splint caused a significant reduction in joint stiffness.