Sequence analysis of the PrP protein from two species of antelope susceptible to transmissible spongiform encephalopathy
- 1 March 1993
- journal article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 131 (1-2), 193-199
- https://doi.org/10.1007/bf01379091
Abstract
The sequence of the coding regions of the PrP genes of the Arabian oryx and greater kudu have been determined and compared with the related sheep and bovine PrP gene sequences. The oryx gene sequence was found to be very closely related to that of the sheep, encoding just one amino acid difference. The greater kudu gene sequence was found to be more closely related to the bovine, encoding four amino acid differences. The possible influence that the gene sequences have on the transmission of spongiform encephalopathy to these antelope species is discussed.Keywords
This publication has 26 references indexed in Scilit:
- Prions and prion proteins 1The FASEB Journal, 1991
- Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob diseaseNature, 1991
- New mutation in scrapie amyloid precursor gene (at codon 178) in Finnish Creutzfeldt-Jakob kindredThe Lancet, 1991
- Different Forms of the Bovine PrP Gene have Five or Six Copies of a Short, G-C-rich Element within the Protein-coding ExonJournal of General Virology, 1991
- Spongiform encephalopathy in an arabian oryx (Oryx leucoryx) and a greater kudu (Tragelaphus strepsiceros)1990
- Linkage of the gene for the scrapie-associated fibril protein (PrP) to the Sip gene in Cheviot sheepVeterinary Record, 1989
- Fibrils from brains of cows with new cattle disease contain scrapie-associated proteinNature, 1988
- Distinct prion proteins in short and long scrapie incubation period miceCell, 1987
- Prions: Novel Infectious PathogensPublished by Elsevier ,1984
- INTERSPECIES TRANSMISSION OF SCRAPIE-LIKE DISEASESThe Lancet, 1975