Potentiation of acetylcholinesterase by a series of quaternary ammonium compounds
- 1 February 1968
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 20 (2), 135-145
- https://doi.org/10.1111/j.2042-7158.1968.tb09703.x
Abstract
Eleven spiran, and two non-spiran, quaternary ammonium compounds have been examined and some of these compounds found to potentiate the hydrolysis of acetylcholine by acetylcholinesterase at high substrate concentrations. The experiments were made in three reaction media, each differing in its ionic composition. The results obtained in these media differ both quantitatively and qualitatively. The mechanism of the potentiation is discussed in terms of the effect of quaternary ammonium compounds on the deacetylation step of acetylcholine hydrolysis.This publication has 17 references indexed in Scilit:
- Acetylcholinesterase: Structural Requirements for Blocking Deacetylation*Biochemistry, 1965
- Acetylcholinesterase: Trimethylammonium-Ion Inhibition of DeacetylationBiochemistry, 1964
- The Mechanism of Action of Acetylcholinesterase: Substrate Inhibition and the Binding of InhibitorsBiochemistry, 1963
- Molecular Mechanisms for Hydrolytic Enzyme Action. II. Inhibition of Acetyl-cholinesterase by Excess SubstrateJournal of the American Chemical Society, 1961
- Effect of Calcium Chloride on Choline EsteraseNature, 1953
- Effect of salt on the hydrolysis of acetylcholine by cholinesterasesArchives of Biochemistry and Biophysics, 1952
- The inhibitory effect of stilbamidine, curare and related compounds and its relationship to the active groups of acetylcholine esterase. Action of stilbamidine upon nerve impulse conductionBiochimica et Biophysica Acta, 1950
- Some Effects of Salts on True CholinesteraseScience, 1945
- Effect of Sodium and Potassium Ions on CholinesteraseNature, 1941
- CCCXXXIII.—Syntheses with ββ′-dichlorodiethyl ether. Part I. Derivatives of tetrahydropyranJournal of the Chemical Society, 1930