THE EXCRETION OF SULFANILAMIDE AND ACETYLSULFANILAMIDE BY THE KIDNEY OF THE RABBIT
- 1 June 1943
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 139 (2), 197-201
- https://doi.org/10.1152/ajplegacy.1943.139.2.197
Abstract
Clearance detns. of sulfanilamide and acetylsulfanilamide were made simultaneously with inulin, creatinine and diodrast on a series of rabbits. The mean clearance of sulfanilamide (1.8 cc/min.) was 30 and 40% of the mean clearance of creatinine and inulin respectively. The mean clearance of acetylsulfanilamide (4.9 cc/min.) was almost identical with that of creatinine. The results obtained were interpreted as meaning that sulfanilamide is excreted by glomerular filtration plus tubular reabsorption and acetylsulfanilamide is excreted solely by glomerular filtration. The clearances of both of these compounds were independent of their plasma conc. as well as the urine flow over the ranges included in the study.This publication has 4 references indexed in Scilit:
- THE TUBULAR REABSORPTION OF UREA, THIOUREA AND DERIVATIVES OF THIOUREA IN THE DOG KIDNEYAmerican Journal of Physiology-Legacy Content, 1941
- THE CONTROL OF RENAL BLOOD FLOW AND GLOMERULAR FILTRATION IN NORMAL MANJCI Insight, 1938
- THE MEASUREMENT OF THE TUBULAR EXCRETORY MASS, EFFECTIVE BLOOD FLOW AND FILTRATION RATE IN THE NORMAL HUMAN KIDNEYJCI Insight, 1938
- THE CLEARANCE, EXTRACTION PERCENTAGE AND ESTIMATED FILTRATION OF SODIUM FERROCYANIDE IN THE MAMMALIAN KIDNEY. COMPARISON WITH INULIN, CREATININE AND UREAAmerican Journal of Physiology-Legacy Content, 1935