Growth characteristics of human colorectal tumours during serial passage in immune-deprived mice
Open Access
- 1 February 1978
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 37 (2), 213-223
- https://doi.org/10.1038/bjc.1978.29
Abstract
The growth characteristics of 6 human colorectal tumours have been examined during serial passage in both male and female immune-deprived mice. Exponential growth is a characteristic feature, especially on very early passages. Growth rates in 5 out of the 6 tumour lines increase during the first few transplant generations. This is accompanied by a shorter exponential growth phase and an increased slope of the growth curves. Lag phases and growth rates for individual tumours are variable within a passage. Growth rates for tumours maintained within the same host are similar, and are at least partially influenced by the host. In one tumour line examined in detail, the increased growth rate is attributable to a decreased cell-loss factor, and the difference in growth rate between human colorectal tumours and their corresponding xenografts may therefore largely be due to a difference in the contribution of this factor.Keywords
This publication has 11 references indexed in Scilit:
- Growth kinetics of human large bowel cancer growing in immune-deprived mice and some chemotherapeutic observationsCancer, 2006
- Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived miceBritish Journal of Cancer, 1978
- Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenograftsBritish Journal of Cancer, 1977
- The therapeutic response of three human tumor lines maintained in immune-suppressed mice.1975
- The growth kinetics of xenografts of human colorectal tumours in immune deprived miceBritish Journal of Cancer, 1975
- A Method of Comparing Differences in Tumour Growth Rates Applied to a Study of the Increasing Growth Capacity of Mouse CarcinomataBritish Journal of Cancer, 1974
- Analysis of the cell kinetics of human solid tumorsCancer, 1971
- The growth rate of human tumours.British Journal of Cancer, 1966
- THE RATES AND PATTERNS OF GROWTH OF 375 TUMORS OF THE LARGE INTESTINE AND RECTUM OBSERVED SERIALLY BY DOUBLE CONTRAST ENEMA STUDY (MALMOE TECHNIQUE).1963
- CELL PROLIFERATION KINETICS IN THE GASTROINTESTINAL TRACT OF MAN. I. CELL RENEWAL IN COLON AND RECTUM*JCI Insight, 1963