Familial predisposition to uterine leiomyomas

Abstract

To study the clinical risk for gynecological disorders in first-degree relatives in families with uterine leiomyoma. Ninety-seven families (215 female patients) were enrolled in this study; 97 patients and 118 of their near family relatives were examined. Leiomyoma was discovered in 24.7% of cases, 2.2 times more frequently (P < 0.001) among the first-degree female relatives in families with two or more verified leiomyoma cases. The rate of PCO disease was about 15% for both groups. These results confirm the concept of distinct predisposition to uterine leiomyoma and the PCO disease in first-degree relatives in families with leiomyoma accumulation.