Inhibition of Cytochrome Oxidase (Paraphenylendiamine Oxidase) of the Thyroid Gland by Thiouracil and Other Compounds
- 1 October 1945
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 60 (1), 148-152
- https://doi.org/10.3181/00379727-60-15123
Abstract
Thiouracil and sulfon-amides inhibited the cytochrome oxidase activity (paraphenylendiamine oxidase) of thyroid tissue (rat) in vitro. The cytochrome oxidase activity of thyroid glands of rats treated with thiouracil was subnormal. Inhibition of cytochrome oxidase activity might possibly be the factor responsible for the antithyroid activity of these drugs. Glutathione, cysteine hydrochloride, and ascorbic acid inhibited cytochrome oxidase activity (paraphenylendiamine oxidase) of thyroid tissue in vitro. Paraminobenzoic acid and paraxanthin did not influence the cytochrome oxidase activity of the thyroid gland.Keywords
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