Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish
- 1 November 1989
- journal article
- Published by Springer Nature in Nature
- Vol. 342 (6247), 238-243
- https://doi.org/10.1038/342238a0
Abstract
Reanalysis of an Old Order Amish pedigree, to include several new individuals and two changes in clinical status, markedly reduces the probability of linkage between bipolar affective disorder and the Harvey-ras-1 oncogene and insulin loci on chromosome 11. This linkage can be excluded using a large lateral extension of the original Amish pedigree.Keywords
This publication has 13 references indexed in Scilit:
- One-Month Prevalence of Mental Disorders in the United StatesArchives of General Psychiatry, 1988
- Searching for a major genetic locus for affective disorder in the old order AmishJournal of Psychiatric Research, 1987
- Bipolar affective disorders linked to DNA markers on chromosome 11Nature, 1987
- Close linkage of c-Harvey-ras-1 and the insulin gene to affective disorder is ruled out in three North American pedigreesNature, 1987
- Molecular genetic evidence for heterogeneity in manic depressionNature, 1987
- Construction of linkage maps with DNA markers for human chromosomesNature, 1985
- Strategies for multilocus linkage analysis in humans.Proceedings of the National Academy of Sciences, 1984
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1983
- A Diagnostic InterviewArchives of General Psychiatry, 1978
- Research Diagnostic CriteriaArchives of General Psychiatry, 1978