Cerebrospinal fluid myelin basic protein as a prognostic marker in patients with head injury

Abstract

Despite increasing interest in identifying biochemical and serologic markers to judge the severity of closed head injury in comatose patients, clinical variables remain the most readily available methods for assessing prognosis. In a series of 35 severely head-injured comatose patients, the cerebrospinal fluid (CSF) level of myelin basic protein (MBP) was analyzed by radio-immunoassay. MBP levels during the first week after injury were significantly correlated with the Glasgow outcome score at 7 days (p < .005), 3 months (p < .005), and 6 months (p < .05) postinjury. Measurement of CSF MBP appears to be a useful laboratory adjunct to clinical assessment, for judging the outcome of severely head-injured patients.