Genetic diversity ofToxoplasma gondiiin animals and humans
- 27 September 2009
- journal article
- review article
- Published by The Royal Society in Philosophical Transactions Of The Royal Society B-Biological Sciences
- Vol. 364 (1530), 2749-2761
- https://doi.org/10.1098/rstb.2009.0087
Abstract
Toxoplasma gondii is one of the most widespread parasites of domestic, wild, and companion animals, and it also commonly infects humans. Toxoplasma gondii has a complex life cycle. Sexual development occurs only in the cat gut, while asexual replication occurs in many vertebrate hosts. These features combine to create an unusual population structure. The vast majority of strains in North America and Europe fall into three recently derived, clonal lineages known as types I, II and III. Recent studies have revealed that South American strains are more genetically diverse and comprise distinct genotypes. These differences have been shaped by infrequent sexual recombination, population sweeps and biogeography. The majority of human infections that have been studied in North America and Europe are caused by type II strains, which are also common in agricultural animals from these regions. In contrast, several diverse genotypes of T. gondii are associated with severe infections in humans in South America. Defining the population structure of T. gondii from new regions has important implications for transmission, immunogenicity and pathogenesis.Keywords
This publication has 147 references indexed in Scilit:
- Recent transcontinental sweep of Toxoplasma gondii driven by a single monomorphic chromosomeProceedings of the National Academy of Sciences, 2007
- Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odorsProceedings of the National Academy of Sciences, 2007
- Polymorphic Secreted Kinases Are Key Virulence Factors in ToxoplasmosisScience, 2006
- Antibodies to Toxoplasma gondii in Patients With Schizophrenia: A Meta-AnalysisSchizophrenia Bulletin, 2006
- Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondiiGenome Research, 2006
- Globalization and the population structure of Toxoplasma gondiiProceedings of the National Academy of Sciences, 2006
- Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondiiProceedings of the National Academy of Sciences, 2006
- How clonal are bacteria?Proceedings of the National Academy of Sciences, 1993
- Virulent strains of Toxoplasma gondii comprise a single clonal lineageNature, 1992
- A clonal theory of parasitic protozoa: the population structures of Entamoeba, Giardia, Leishmania, Naegleria, Plasmodium, Trichomonas, and Trypanosoma and their medical and taxonomical consequences.Proceedings of the National Academy of Sciences, 1990