Biological Difference Cadminum and Zinc Turnover

Abstract

In rat plasma, ¹⁰⁹Cd was mainly associated with α-globulin fraction and ⁶⁵Zn was bound to and β-globulins. Subcutaneously injected cadmium chloride Cd 109 and zinc chloride Zn 65 resulted in rapid clearance of ¹⁰⁹Cd from blood plasma, as compared to ⁶⁵Zn. Blood cells accumulated ⁶⁵Zn more rapidity than ¹⁰⁹Cd. Greatest uptakes of ¹⁰⁹Cd per unit weight of tissue were by liver, kidneys, and pancreas, but that of ⁶⁵Zn was by the pancreas. From all tissues, ⁶⁵Zn was depleted eventually. In the first six hours after isotope dose, testis tissue concentrated more ¹⁰⁹Cd than ⁶⁵Zn. In testes, ⁶⁵Zn-influx continued for 168 hours, without further ¹⁰⁹Cd increase. Both isotopes were excreted predominantly via intestinal tract. Fecal and urinary excretion of ¹⁰⁹Cd and ⁶⁵Zn was accelerated by 2,3-dimercapto-1-propanol Results Indicate ¹⁰⁹Cd follows metabolic pathways different from those of ⁶⁵Zn.