Sox9 induces testis development in XX transgenic mice
Top Cited Papers
- 1 July 2001
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 28 (3), 216-217
- https://doi.org/10.1038/90046
Abstract
Mutations in SOX9 are associated with male-to-female sex reversal in humans1,2. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.Keywords
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