STUDIES ON THE RELATIVE EFFECTS OF PROSTAGLANDINS, BRADYKININ, 5‐HYDROXYTRYPTAMINE AND HISTAMINE ON THE SYNOVIAL MICROCIRCULATION IN DOGS
Open Access
- 1 March 1976
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 56 (3), 313-316
- https://doi.org/10.1111/j.1476-5381.1976.tb07644.x
Abstract
1 The relative effects of prostaglandins E1, E2, F1α, F2α, bradykinin, histamine and 5-hydroxytryptamine (5-HT) on the canine synovial microcirculation were investigated using the rate of clearance of radioactive xenon (133Xe) as an index of synovial perfusion. 2 All the compounds tested, except prostaglandin F1α, produced a vasodilator effect. The descending order of potency of the active compounds was (i) prostaglandin E1, (ii) prostaglandin E2 and bradykinin, (iii) histamine and 5-HT, (iv) prostaglandin F2α. The most potent compound tested, prostaglandin E1 produced an effect in nanogram amounts in each joint. 3 Prostaglandin F2α has been reported to have an anti-inflammatory action; however no evidence was found of antagonism of prostaglandin E1 by two dose levels of prostaglandin F2α. 4 Preliminary studies showed that threshold doses of prostaglandin E1 did not potentiate the vasodilator action of threshold or sub-threshold doses of bradykinin in the dog synovium.Keywords
This publication has 11 references indexed in Scilit:
- THE ROLE OF PROSTAGLANDINS IN RABBIT MONOARTICULAR ARTHRITISBritish Journal of Pharmacology, 1974
- Prostaglandins, Aspirin-like Drugs and AnalgesiaNature New Biology, 1972
- Derivation of knee joint synovial perfusion. Using the Xenon (133Xe) clearance technique.Annals Of The Rheumatic Diseases, 1970
- Microcirculatory effects of prostaglandinsCanadian Journal of Physiology and Pharmacology, 1969
- Effects of prostaglandins PGF2α and PGE1 on vascular permeabilityThe Journal of Pathology and Bacteriology, 1968
- The presence of a kinin in inflammatory synovial effusion from arthritides of varying etiologiesArthritis & Rheumatism, 1967
- The Histamine Content of Human Synovial Membrane: A Spectrofluorometric AssayActa Rheumatologica Scandinavica, 1965
- PLASMA KININS AND OTHER VASOACTIVE COMPOUNDS IN ACUTE INFLAMMATIONAnnals of the New York Academy of Sciences, 1964
- MICROCIRCULATORY ASPECTS OF TISSUE INJURY*Annals of the New York Academy of Sciences, 1964
- STUDIES ON INFLAMMATIONThe Journal of cell biology, 1961