cAMP as a second messenger in central blood pressure control
- 1 January 1975
- journal article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 290 (4), 419-423
- https://doi.org/10.1007/bf00499953
Abstract
Injections of dibutyryl cyclic adenosine 3′,5′-monophosphate in doses of 125, 250 and 500 μg/kg into the lateral cerebral ventricle of anaesthetised cats produced dose dependent increases in blood pressure and heart rate, while doses of 50, 100 and 200 μg/kg imidazole-4-acetic acid, a stimulator of phosphodiesterase, exerted an opposite effect. The results are discussed in the light of the hypothesis that the activity of cardiovascular centres is determined by their concentration of cyclic AMP.Keywords
This publication has 11 references indexed in Scilit:
- Comparison of the effects of biogenic amines on cyclic GMP and cyclic AMP levels in mouse cerebellumin vitroBrain Research, 1975
- Histamine H2 receptors and cyclic AMP in brainLife Sciences, 1974
- Central beta-adrenoceptor sites and ouabain actionPharmacological Research Communications, 1974
- CENTRAL α‐ AND β‐ADRENOCEPTORS MODIFYING ARTERIAL BLOOD PRESSURE AND HEART RATE IN CONSCIOUS CATSBritish Journal of Pharmacology, 1974
- Comparative studies on central factors contributing to the hypotensive action of propranolol, alprenolol, and their enantiomersCardiovascular Research, 1974
- Metabolism and functions of cyclic amp in nerveProgress in Neurobiology, 1973
- ON THE REGULATION OF ADENYL CYCLASE ACTIVITY IN THE RAT PINEAL GLANDAnnals of the New York Academy of Sciences, 1971
- Some properties of cyclic 3′, 5′-nucleotide phosphodiesterase of mouse brain: effects of imidazole-4-acetic acid, chlorpromazine, cyclic 3′,5′-GMP, and other substancesBrain Research, 1970
- Some Aspects of the Biological Role of Adenosine 3',5'-monophosphate (Cyclic AMP)Circulation, 1968
- Stimulation of Sympathetic Centers by HistamineCirculation Research, 1957