The Role of Cyclic 3', 5'-Adenosine Monophosphate in Neuromuscular Transmission
- 1 December 1973
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 29 (6), 420-424
- https://doi.org/10.1001/archneur.1973.00490300082011
Abstract
The neuromuscular transmission defect of the Eaton-Lambert syndrome in which calcium-dependent acetylcholine release by nerve impulse is defective was partially corrected by epinephrine and methylxanthines. These drugs act on the adenyl cyclase system to increase the content of cyclic 3', 5'-adenosine monophosphate in cells and have effects similar to those of calcium. No meaningful change was seen with these drugs in classical myasthenia patients or in normal subjects. Alpha-adrenergic stimulants showed the same action as epinephrine, while the β-adrenergic stimulants worsened the transmission block. However, the epinephrine-induced relief was potentiated by the β-adrenergic blocker but was eliminated by the α-adrenergic blocker. These findings suggest that the presynaptic adrenergic modulation in Eaton-Lambert syndrome is mediated through the a-receptor.Keywords
This publication has 14 references indexed in Scilit:
- Caffeine, Calcium, and Eaton-Lambert SyndromeArchives of Neurology, 1972
- Intermittent defect of acetylcholine release in myasthenia gravisNeurology, 1971
- Effects of catecholamines on the neuromuscular junction in the rat diaphragmThe Journal of Physiology, 1970
- Cell Communication, Calcium Ion, and Cyclic Adenosine MonophosphateScience, 1970
- Stimulation of DNA synthesis and mitotic activity of thymic lymphocytes by cyclic adenosine 3′5′-monophosphateExperimental Cell Research, 1969
- Effects of catecholamines on the cholinergic neuromuscular transmission in fish red muscleThe Journal of Physiology, 1969
- Cyclic adenosine monophosphate, CA++, and membranes.Proceedings of the National Academy of Sciences, 1968
- ADRENOTROPIC RECEPTORS IN SKELETAL MUSCLEAnnals of the New York Academy of Sciences, 1967
- EFFECTS OF SYMPATHOMIMETIC AMINES ON NEUROMUSCULAR TRANSMISSIONBritish Journal of Pharmacology and Chemotherapy, 1966
- Some effects produced by adrenaline upon neuromuscular propagation in ratsThe Journal of Physiology, 1958