Cortisol Induction of Growth Hormone Synthesis in a Clonal Line of Rat Pituitary Tumor Cells in Culture
- 31 October 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 166 (3905), 633-634
- https://doi.org/10.1126/science.166.3905.633
Abstract
Growth hormone synthesis increased markedly after addition of glucocorticoids at physiological concentrations to cultures of the GH1 line of rat pituitary tumor cells. Stimulation of hormone protein synthesis by corticosteroids was selective, since (i) the rate of hormone synthesis increased while total protein synthesis decreased, and (ii) cortisol analogs, biologically inactive metabolites, and sex steroids did not induce growth hormone synthesis.Keywords
This publication has 8 references indexed in Scilit:
- Cortisol stimulation of growth hormone production by monkey adenohypophysis in tissue cultureBiochemical and Biophysical Research Communications, 1968
- Growth Hormone and Insulin Levels in Weanling Rats with Ventromedial Hypothalamic LesionsEndocrinology, 1968
- Establishment of Clonal Strains of Rat Pituitary Tumor Cells That Secrete Growth Hormone1,2Endocrinology, 1968
- Effects of Cortisol and Diethylstilbestrol on Growth Hormone Release by Rat Pituitary in vitro.Experimental Biology and Medicine, 1967
- Establishment of Four Functional, Clonal Strains of Animal Cells in CultureScience, 1966
- Human Growth HormoneNew England Journal of Medicine, 1964
- An improved nutrient solution for diploid Chinese hamster and human cell linesExperimental Cell Research, 1963
- Measurement of the incorporation of radioactive amino acids into protein by a filter-paper disk methodArchives of Biochemistry and Biophysics, 1961