EXPERIMENTAL OBSERVATIONS ON THE EFFECT OF VARIOUS DIURETICS WHEN INJECTED DIRECTLY INTO ONE RENAL ARTERY OF THE DOG 1

Abstract

In acute experiments on dogs anesthetized with dial intraperitoneally various diuretics were introduced directly into the left renal artery. Novasurol, salyrgan and theocine-sodium-acetate in small doses produced a diuresis from the left kidney and little change in urine from right kidney; in larger doses urine flow from each kidney was about equally increased; with still larger doses an active diuresis occurred from the right kidney and no increase or a decrease in urine from the left. Caffeine-citrate, theobromine-sodium-salicylate, theophylline-ethylene-diamine, theophylline-calcium-salicylate, urea and digitan in doses of all sizes produced a diuresis with about the same urine flow from each kidney.