Superparamagnetic Agents in Magnetic Resonance Imaging: Physicochemical Characteristics and Clinical Applications A Review
- 1 January 1998
- journal article
- review article
- Published by Taylor & Francis in Journal of Drug Targeting
- Vol. 6 (3), 167-174
- https://doi.org/10.3109/10611869808997890
Abstract
Superparamagnetic agents in magnetic resonance imaging: physico-chemical characteristics and clinical applications. Superparamagnetic agents have been the subject of extensive research over the last decade. They consist of iron oxide nanoparticles which are highly effective in Magnetic Resonance Imaging (MRI). The particle size varies widely and influences their physico-chemical and pharmacokinetic properties. Their main present and future applications by the parenteral route are: imaging of gastrointestinal tract, liver and spleen, lymph nodes. Ultrasmall superparamagnetic iron oxide particles (USPIO) are also blood pool agents which could be used for perfusion imaging (i.e. brain or myocardial ischemic diseases) as well as for imaging of vessels in Magnetic Resonance Angiography. These agents open up an important field of research into more specific agents adapted to clinicians' needs in diagnostic imaging.Keywords
This publication has 33 references indexed in Scilit:
- Oral superparamagnetic contrast agent (ferumoxsil): Tolerance and efficacy in MR imaging of gynecologic diseasesJournal of Magnetic Resonance Imaging, 1995
- Liver metastases: safety and efficacy of detection with superparamagnetic iron oxide in MR imaging.Radiology, 1994
- SHU 555AInvestigative Radiology, 1994
- Enhancement of MR angiography with iron oxide: preliminary studies in whole-blood phantom and in animals.American Journal of Roentgenology, 1994
- Superparamagnetic iron oxides as positive MR contrast agents: In vitro and in vivo evidenceMagnetic Resonance Imaging, 1993
- MR Imaging of Slow Axonal Transport in VivoExperimental Neurology, 1993
- Abdominal MRI using a negative contrast agentThe British Journal of Radiology, 1993
- Superparamagnetic iron oxide particles and positive enhancement for myocardial perfusion studies assessed by subsecond T1-weighted MRIMagnetic Resonance Imaging, 1993
- First clinical trial of a new superparamagnetic iron oxide for use as an oral gastrointestinal contrast agent in MR imaging.Radiology, 1990
- Le phénomène de superparamagnétismeRevue de Physique Appliquée, 1981