Symptoms and the genetics of schizophrenia: implications for diagnosis
- 1 December 1984
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 141 (12), 1541-1546
- https://doi.org/10.1176/ajp.141.12.1541
Abstract
To determine whether genetic influences in schizophrenia are related to the symptoms specified by diagnostic criteria, the case histories of 151 pairs of monozygotic twins from 5 twin studies of schizophrenia were rated for positive and negative symptoms. Concordance rates in monozygotic twins were significantly higher when probands had a greater number of negative symptoms; no evidence of a similar relationship was found for positive symptoms. Negative symptoms may be characteristic of schizophrenia in which there is a greater genetic component. Results have important implications for determining diagnostic criteria and understanding the pathogenesis of schizophrenia.This publication has 32 references indexed in Scilit:
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