Thiabendazole Probable Cure for Trichinosis

Abstract

THIABENDAZOLE ( 2-( 4′thiazolyl) -benzimidazole) represents a new class of broad spectrum anthelmintics with a wide range of activity.¹ In addition to its marked potency against helminths, it has negligible mammalian toxicity. This drug has been the subject of intense veterinary research.^2-7 It is limited to investigational use in humans, but is currently being evaluated in this country and several foreign areas. Studies from Brazil⁸ and Liberia⁹ indicate that it is highly effective in cases of human strongyloidiasis. There were no serious side effects in the total 140 cases reported. In a small number of patients treated, transient dizziness, drowsiness, nausea, or vomiting occurred. One child receiving over 2 1/2 times the normal dosage developed a papular eruption. Some of these minor side effects might be the result of the release of toxic material derived from dead parasites. The authors¹⁰ recently reported the first systemic use