Further exclusion data for the Von Recklinghausen neurofibromatosis gene: a genetic linkage study of 19 polymorphic markers.
- 1 September 1987
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 24 (9), 534-536
- https://doi.org/10.1136/jmg.24.9.534
Abstract
Linkage analysis on a panel of 15 Von Recklinghausen neurofibromatosis (VRNF) families with 19 polymorphic markers was carried out using the computer programme M-link. Our findings have excluded VRNF from a significant proportion of the genome. Von Recklinghausen neurofibromatosis (VRNF) is one of the commonest autosomal dominant disorders in man with a prevalence of at least 20/100,0001 of the population. The mapping of the VRNF gene will be an important step towards our eventual understanding of the pathogenesis of the disease and a closely linked marker would be immediately applicable in prenatal diagnosis where appropriate.Keywords
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