INHIBITION OF THE PYLORIC SPHINCTER REGION BY THE DIGESTION PRODUCTS OF FAT

Abstract

Studies made with the tandem balloon method on trained dogs during fasting demonstrated that the introduction of fatty acids or soaps into the distal duodenum inhibited the motility of the pyloric antrum, sphincter, duodenal bulb and distal duodenum in a manner qualitatively similar to that produced by natural fate. The test substances employed exhibited considerable individual variation, but usually the order of decreasing activity was soaps, fatty acids, neutral fats. The evidence indicated that if natural fats were administered, they initiated the inhibitory action and the digestion products, with the exception of glycerine, continued the influence.