Comparison of the effect of somatostatin on gastrointestinal function in the conscious and anaesthetized cat and on the isolated cat pancreas.

Abstract

Somatostatin, 10 .mu.g kg-1 h-1, inhibited gastric acid and pepsin secretion stimulated by pentagastrin, 8 .mu.g kg-1 h-1, in conscious and anesthetized cats with chronically implanted gastric fistulae. In the acutely surgically prepared anesthetized cat. Somatostatin inhibited pepsin secretion but produced little inhibition of gastric acid secretion or mucosal blood flow. Secretin stimulated pancreatic juice volume was not significantly reduced in acutely prepared anesthetized cats, but there was a limited reduction of cholecystokinin-pancreozymin stimulated pancreatic amylase secretion and gall bladder contraction. Somatostatin had neither stimulatory nor inhibitory effects on electrolyte and amylase secretion in the isolated saline-perfused cat pancreas. Some of the effects of somatostatin may depend on the interaction on the target cell of other factors, nervous or humoral which may vary in different experimental preparations.