Genetic lesions induced by chemicals in spermatozoa and spermatids of mice are repaired in the egg.
- 1 January 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (1), 435-437
- https://doi.org/10.1073/pnas.76.1.435
Abstract
Conclusive proof that the mouse egg is capable of carrying out repair of genetic lesions present in the male genome was obtained through dominant-lethal studies of chemically treated spermatozoa and spermatids and through cytological analysis of 1st-cleavage metaphases. The maximum difference in repair capability between stocks of females, found for isopropyl methanesulfonate treatment, was large; considerably smaller differences were found for ethyl methanesulfonate, triethylenemelamine and benzo[a]pyrene treatments; and no difference was found for X-ray treatment.This publication has 9 references indexed in Scilit:
- Changing levels of UV light and carcinogen-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturationExperimental Cell Research, 1978
- Ultraviolet-light-induced unscheduled DNA synthesis by resting and growing mouse oocytesMutation Research, 1978
- Ultraviolet light-induced unscheduled DNA synthesis in mouse oocytes during meiotic maturationNature, 1975
- [The mutagenic effect of thioTEPA in laboratory mice. V. The influence of female genotype on the realization of dominant lethal mutations induced in male spermatids].1975
- Chemically induced dominant-lethal mutations and cell killing mouse oocytes in the advanced stages of follicular development.1971
- Strain and sex variations in the sensitivity of mice to dominant-lethal induction with ethyl methanesulfonateMutation Research, 1969
- On the Relationship between Genetic and Somatic Sensitivity to Radiation Damage in Inbred Mouse StrainsRadiation Research, 1967
- Embryonic Lethality of Various Mouse Strains as a Consequence of X-Irradiation-Induced Injuries of the Father's SpermatozoaRadiation Research, 1965
- Radiation Dose Rate and Mutation FrequencyScience, 1958