Palladium-Catalyzed Homocoupling Reactions between Two Csp3−Csp3 Centers
- 19 June 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (14), 2285-2288
- https://doi.org/10.1021/ol0258536
Abstract
A novel palladium-catalyzed coupling reaction between two Csp3−Csp3 centers has been investigated. This protocol is initiated by the oxidative addition of an α-halo carbonyl compound to a palladium(0) species, followed by the double transmetalation. The key dialkyl palladium intermediate undergoes reductive elimination to form the desired coupling product.Keywords
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