Reduction in Hepatic Triiodothyronine Binding Capacity Induced by Fasting
- 1 October 1977
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 101 (4), 1331-1334
- https://doi.org/10.1210/endo-101-4-1331
Abstract
Triiodothyronine (T3) receptor kinetics were determined in liver nuclei isolated from fasting and fed rats. Although affinity equilibrium constants (Ka) did not differ in the 2 groups, mean (.+-. SE) maximal binding capacity (MBC) was reduced significantly to .30 .+-. .05 nM/mg DNA in fasting compared to .46 .+-. .07 nM/mg DNA (P < .01) in the fed state. This observed decrease in MBC during fasting apparently could not be accounted for by differential rates of loss of either DNA or of the receptor during the period of incubation.This publication has 6 references indexed in Scilit:
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