The Genexpress Index: a resource for gene discovery and the genic map of the human genome.
Open Access
- 1 October 1995
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Genome Research
- Vol. 5 (3), 272-304
- https://doi.org/10.1101/gr.5.3.272
Abstract
Detailed analysis of a set of 18,698 sequences derived from both ends of 10,979 human skeletal muscle and brain cDNA clones defined 6676 functional families, characterized by their sequence signatures over 5750 distinct human gene transcripts. About half of these genes have been assigned to specific chromosomes utilizing 2733 eSTS markers, the polymerase chain reaction, and DNA from human-rodent somatic cell hybrids. Sequence and clone clustering and a functional classification together with comprehensive data base searches and annotations made it possible to develop extensive sequence and map cross-indexes, define electronic expression profiles, identify a new set of overlapping genes, and provide numerous new candidate genes for human pathologies.Keywords
This publication has 77 references indexed in Scilit:
- Integration of Transcript and Genetic Maps of Chromosome 16 at Near-1-Mb Resolution: Demonstration of a “Hot Spot” for Recombination at 16p12Genomics, 1995
- Assessing Mapping Progress in the Human Genome ProjectScience, 1994
- Cataloging of the Genes Expressed in Human Keratinocytes: Analysis of 607 Randomly Isolated cDNA SequencesBiochemical and Biophysical Research Communications, 1994
- The 1993–94 Généthon human genetic linkage mapNature Genetics, 1994
- A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clonesHuman Molecular Genetics, 1993
- Generation of Expressed Sequence Tags of Random Root cDNA Clones of Brassica napus by Single-Run Partial SequencingPlant Physiology, 1993
- Identification of protein coding regions by database similarity searchNature Genetics, 1993
- Genome mapping: cDNA approachesCurrent Opinion in Genetics & Development, 1992
- Chromosomal assignment of 46 brain cDNAsGenomics, 1992
- Basic Local Alignment Search ToolJournal of Molecular Biology, 1990