Stability of Isoniazid in Aqueous Solutions and Plasma
- 1 August 1960
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 104 (4), 560-562
- https://doi.org/10.3181/00379727-104-25907
Abstract
Isoniazid is stable for several weeks in aqueous and buffered solutions at pH values below 8 and at low temperature. It is unstable in human and rabbit plasma whether added to pure plasma or present after oral or parenteral administration. Instability is enhanced by increased temperature, but is quite marked at refrigerator temperature. The presence of a factor in blood causes changes in the chemical state of isoniazid so that it no longer reacts with the reagent used in the chemical assay method of Poole and Meyer. The importance of these findings for the evaluation of INH bioassay is discussed.Keywords
This publication has 1 reference indexed in Scilit:
- Comparison of New Chemical Method of Determining Isonicotinoyl Hydrazide in Serum with Microbiological AssayExperimental Biology and Medicine, 1958